Ionisation constants and partition coefficients of some analgesically active 2-benzylbenzimidazole derivatives and related compounds
- 1 October 1966
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 18 (10) , 677-683
- https://doi.org/10.1111/j.2042-7158.1966.tb07782.x
Abstract
The ionisation constants (in aqueous ethanol) and the partition coefficients (in a water-cyclohexane system) of some analgesically active 2-benzylbenzimidazole derivatives and related compounds are reported. The results are discussed in terms of structure-activity relationships.This publication has 13 references indexed in Scilit:
- Drug Partitioning IJournal of Pharmaceutical Sciences, 1964
- The Ionization Constants, Ultraviolet and Infrared Spectra of Some Substituted BenzimidazolesThe Journal of Organic Chemistry, 1964
- Benzimidazol‐Derivate und verwandte Heterocyclen. II. Synthese von 1‐Aminoalkyl‐2‐benzyl‐benzimidazolenHelvetica Chimica Acta, 1960
- ber neue starkwirkende Analgetika und ihre klinische ErprobungKlinische Wochenschrift, 1958
- Synthese basisch substituierter, analgetisch wirksamer Benzimidazol-DerivateCellular and Molecular Life Sciences, 1957
- Some Physico-Chemical Factors in Drug ActionJournal of Pharmacy and Pharmacology, 1957
- Synthetic Analgesics: Stereochemical ConsiderationsJournal of Pharmacy and Pharmacology, 1954
- THE CHEMISTRY OF ANTI-PERNICIOUS ANÆMIA FACTORSJournal of Pharmacy and Pharmacology, 1951
- Aciditätsmessungen an unbeständigen SubstanzenHelvetica Chimica Acta, 1940
- RELATIONS BETWEEN THE STRUCTURE AND STRENGTH OF CERTAIN ORGANIC BASES IN AQUEOUS SOLUTIONJournal of the American Chemical Society, 1932