Vomeronasal Epithelial Cells of Human Fetuses Contain Immunoreactivity for G Proteins, Goalpha and Gialpha2
Open Access
- 1 June 2001
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemical Senses
- Vol. 26 (5) , 517-522
- https://doi.org/10.1093/chemse/26.5.517
Abstract
Two G protein subfamilies, Goα and Giα2, were identified and localized immunohistochemically in the vomeronasal organ (VNO) of 5-month-old human fetuses. Immunoreactivity for Goα and Giα2 was present in a subset of vomeronasal epithelial cells. Prominent immunoreactivity was observed in apical processes and their apical terminals facing onto the vomeronasal lumen. Nerve fibers associated with the VNO exhibited intense immunoreactivity for Goα and weak immunoreactivity for Giα2. Since Goα and Giα2 are characteristically expressed and coupled with putative pheromone receptors in rodent vomeronasal receptor neurons, the present results suggest the possibility that vomeronasal epithelial cells containing Goα and Giα2 in human fetuses are chemosensory neurons.Keywords
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