The Effects of Treatment with Interleukin-1α on Platelet Recovery after High-Dose Carboplatin
Open Access
- 18 March 1993
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 328 (11) , 756-761
- https://doi.org/10.1056/nejm199303183281103
Abstract
Thrombocytopenia is a frequent side effect of cancer chemotherapy and commonly limits attempts to escalate drug doses. To determine whether interleukin-1α could ameliorate carboplatin-induced thrombocytopenia, we combined it with high-dose carboplatin in 43 patients with advanced neoplasms.Keywords
This publication has 25 references indexed in Scilit:
- Influence of mobilized peripheral blood cells on the hematopoietic recovery by autologous marrow and recombinant human granulocyte- macrophage colony-stimulating factor after high-dose cyclophosphamide, etoposide, and cisplatinBlood, 1992
- Reduction by Granulocyte Colony-Stimulating Factor of Fever and Neutropenia Induced by Chemotherapy in Patients with Small-Cell Lung CancerNew England Journal of Medicine, 1991
- Recombinant Granulocyte-Macrophage Colony-Stimulating Factor after Autologous Bone Marrow Transplantation for Lymphoid CancerNew England Journal of Medicine, 1991
- Preliminary report: effects of interleukin-1 on platelet countsThe Lancet, 1990
- Biology of interleukin 1The FASEB Journal, 1988
- Synergy of interleukin 1 and granulocyte colony-stimulating factor: in vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice.Proceedings of the National Academy of Sciences, 1987
- Clinical value of the creatinine clearance before the administration of chemotherapy with cisplatinCancer, 1987
- Interleukin 1 stimulates granulocyte macrophage colony-stimulating activity release by vascular endothelial cells.Journal of Clinical Investigation, 1986
- Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2.Journal of Clinical Investigation, 1986
- Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAsNature, 1985