Cytodifferentiated Renal Tumors Occurring with Wilms’ Tumors of the Opposite Kidneys: Report of Two Cases

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Abstract
The most common differentiated renal tumor of early childhood is the congenital mesoblastic nephroma. Well-differentiated forms of Wilms’ tumor may present a difficult differential diagnosis from these benign neoplasms. The cases of two patients found to have well-differentiated renal neoplasms after being treated for Wilms’ tumor of the opposite kidneys are reported. The second neoplasms were composed of a benign-appearing stroma with mature skeletal muscle and completely lacked any embryonal, nephroblastic tissue. These benign-appearing neoplasms may be cytodifferentiated variants of Wilms’ tumor. Though tumors of this type may have a malignant potential, there is evidence to indicate that they may be approached more conservatively than the usual nephroblastoma. In cases of bilateral Wilms’ tumor, welldifferentiated tumors might be treated by partial nephrectomy alone, with careful preservation of functional renal tissue.

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