Mann-Williamson Rat

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Abstract
Albino rats of Sprague-Daw-ley strain were used for a modified Mann-Williamson operation. The duodenum was transsected at the pylorus and its proximal end was closed; the jejunum was transsected 1 cm below the ligament of Treitz; its distal end was anastomosed to the stomach; the proximal was anastonosed end to side to the cecum. Seventeen rats survived for only 7 days, and most of them had ulcers in the prostomach; 27 rats survived for an average of 68 days and most of them had stomal ulcers. It is believed that in the 1st group obstruction at the gastrojejunal anastomosis and increased intragastric pressure were the cause of ulcers in the prostomach, similar to those seen in the pylorus-ligated mouse. It is felt that the 2nd group represents typical Mann-Williamson ulcer in rat. Formation of marginal ulcers in the second group may be related to inadequate blood supply in the region of the gastrojejunal anastomosis.

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