BACTERIOPHAGY IN URINARY INFECTION PART II. BACTERIOPHAGY IN THE BLADDER

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Abstract
In experiments upon rabbits as well as in experiments with surviving bladder tissue of rabbits, it was observed that bacteriophage occurs in the urine only when the urine contains lysogenic (carrier) strains of Bacillus coli. Artificial introduction of bacteriophage into the body may result in its transitory presence in the urine, but it is eliminated within 24 hours. Bacteriophagy can take place in the bladder but the urine exercises an inhibitory action. Factors other than bacteriophagy play a role in the elimination of bacteria from the bladder, although the bacteriophage may affect these other factors. The mucus itself acts directly upon the bacteria, and dead bladder tissue releases a principle resembling bacteriophage. Apparently the phenomenon of bacteriophagy in the bladder is not identical with that which occurs in the test tube.