Translocation 2;11 in a fibroma of tendon sheath
- 1 May 1998
- journal article
- case report
- Published by Wiley in Histopathology
- Vol. 32 (5) , 433-435
- https://doi.org/10.1046/j.1365-2559.1998.00390.x
Abstract
Aims: To determine whether fibromas of tendon sheath represent a reactive fibrosing process or whether they are neoplastic, we investigated the chromosomes of the proliferating cells. A clonally occurring karyotypic abnormality would be an argument in favour of these fibromas being neoplastic.Methods and results: A biopsy specimen of a fibroma of tendon sheath was cultured after collagenase exposure leading to dissociation of the tissue. The cultured cells were harvested after 4 days and chromosome analysis done according to standard procedures. Ten out of 20 karyotyped cells showed an identical chromosome abnormality characterized by a t(2;11)(q31–32;q12). The other 10 cells showed a normal 46,XX karyotype.Conclusion: The clonally occurring chromosome abnormality found in this fibroma of tendon sheath suggests that this proliferation is neoplastic and not a reactive fibrosing process.Keywords
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