Studies of the Local Immune Response to Pyelonephritis in the Rabbit

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Abstract
The presence of antibody-forming cells in kidney, spleen, bone marrow, and thymus of animals with pyelonephritis was determined with a modified procedure for hemolysis in gel. Antibody-forming cells in the kidney were confined to areas with histological evidence of pyelonephritis. Antibody also accumulated in the renal pelvis. Although conventional agglutination procedures did not demonstrate the presence of urinary antibody, both IgM and IgG antibody to bacteria could be found in the urine during renal infection when a biological amplification system was used. In contrast to previous studies with the rabbit model, the present studies have found IgM to be the predominant antibody synthesized in both the spleen and the pyelonephritic kidney. Maintenance of levels of antibody in serum during chronic pyelonephritis in the rabbit did not depend on continued synthesis of antibody within the kidney or spleen. Removal of the antigenic stimulus by nephrectomy of the pyelonephritic kidney likewise did not affect subsequent levels of circulating antibody.

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