Hydrolysis of oligoribonucleotides by α‐helical basic peptides
- 1 August 1991
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 38 (2) , 154-160
- https://doi.org/10.1111/j.1399-3011.1991.tb01423.x
Abstract
Poly(Leu-Lys-Lys-Leu) increases markedly the rate of hydrolysis of oligoribonucleotides. The polypeptide adopts an α-helical conformation in water in the presence of salt. Non-helical poly(Pro-Lys-Lys-Leu) is much less active. Ac-Leu-Lys-Lys-Leu-NHEt has no hydrolytic activity. Oligotetrapeptides Ac-(Leu-Lys-Lys-Leu)n-NHEt with increasing chain-length have been prepared by solid phase synthesis to evaluate the critical chain-length required for the hydrolytic activity. It is possible to correlate the activity to the propensity to form α-helices.Keywords
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