Biologically Active Oligodeoxyribonucleotides - IV: Anti-HIV-1 Activity of Tgggag Having Hydrophobic Substituent at Its 5′-End via Phosphodiester Linkage
- 1 January 1996
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 15 (1-3) , 531-538
- https://doi.org/10.1080/07328319608002403
Abstract
Hexadeoxyribonucleotides (6-mers) having a 5′-TGGGAG-3′ sequence bearing hydrophobic substituents at their 5′-ends via phosphodiester linkages were prepared and evaluated for anti-HIV-1 activity in vitro. Some of these modified 6-mers showed weak anti-HIV-1 activities and they were less potent than the 6-mer having a DMTr group directly attached at its 5′-terminus.Keywords
This publication has 9 references indexed in Scilit:
- Short, Terminally Phosphorylated Oligoriboguanylic Acids Effectively Inhibit Cytopathicity Caused by Human Immunodeficiency VirusBiochemical and Biophysical Research Communications, 1994
- Biologically Active Oligodeoxyribonucleotides - II1: Structure Activity Relationships of Anti-HIV-1 Pentadecadeoxyribonucleotides Bearing 5′-End-ModificationsNucleosides and Nucleotides, 1994
- Mechanism of inhibition of HIV-1 infectionin vitroby guanine-rich oligonucleotides modified at the 5′ terminal by dimethoxytrityl residueNucleic Acids Research, 1994
- Use of hydrophobic substituents in controlling self-assembly of oligonucleotidesJournal of the American Chemical Society, 1993
- Synthesis and physical properties ofanti-HIV antisense oligonucleotides bearing terminal lipophilic groupsNucleic Acids Research, 1992
- Attachment of vitamin E derivatives to oligonucleotides during solid-phase synthesisTetrahedron Letters, 1992
- A new class of antivirals: antisense oligonucleotides combined with a hydrophobic substituent effectively inhibit influenza virus reproduction and synthesis of virus‐specific proteins in MDCK cellsFEBS Letters, 1990
- Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugatesNucleic Acids Research, 1990
- Cholesteryl-conjugated oligonucleotides: synthesis, properties, and activity as inhibitors of replication of human immunodeficiency virus in cell culture.Proceedings of the National Academy of Sciences, 1989