THE ACTION OF ANESTHESIA ON THE HISTAMINE RELEASE IN ANAPHYLACTIC SHOCK

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Abstract
Perfused lungs from guinea pigs sensitized to egg albumin released no detectable amts. of histamine upon inj. of the antigen, when the perfusion fluid contained ether in concs. above 0.25% or urethane above 0.25%. The same results were obtained in most of a series of expts., in which ether was introduced via artificial respiration. Incubation with antigen of lung lobes, uterine horns or seminal vesicles from sensitized animals resulted in no release of histamine, when these tissues had been in previous contact with ether or urethane. Control expts., in which tissues from the animals used in these expts. were incubated in anesthetic-free antigen soln., showed that the animals were well sensitized and that their tissues released histamine in "shock." The possibility that the suppression of the histamine release from these tissues was due to an action of the anesthetic on the antigenic properties of egg albumin was ruled out experimentally. The mode of action of ether and urethane in preventing fatal anaphylactic shock is discussed with regard to the findings reported above.

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