Syntheses and .BETA.-adrenergic blocking activities of the optical isomers of 8-acetonyloxyl-5-(3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy)-3,4-dihydrocarbostyril.

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Abstract
The optical isomers of 8-acetonyloxy-5-[3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy]-3,4-dihydrocarbostyril were prepared from the optically active epichlorhydrin, and their .beta.-adrenergic blocking activities were examined in guinea pigs. The (S)(-)-isomer was .apprx. 200 times more potent on atrial and 100 times more potent on tracheal preparations, and was also about 3 times more .beta.1-selective than the (R)(+)-isomer.

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