α‐Helical solenoid model for the human involucrin
- 9 May 2000
- journal article
- Published by Wiley in FEBS Letters
- Vol. 473 (2) , 127-131
- https://doi.org/10.1016/s0014-5793(00)01502-7
Abstract
Involucrin is a key component of the cross‐linked envelope of terminally differentiated keratinocytes. The human molecule largely consists of 10 residue repeats and forms a thin 460 Å long rod. Summarized experimental data and a detailed stereochemical analysis made with computer modeling resulted in a structural model for the involucrin molecule. The suggested structure is a left‐handed α‐helical solenoid built of a tandem array of helix‐turn‐helix folds. The structure enables us to explain the whole set of experimental data and residue conservations within the repeats. It is ideally suited to serve as a scaffold for cell envelope assembly and proposes a possible mode of the intermolecular interactions of involucrin during cell cornification.Keywords
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