Rank Order of Sarcoma Susceptibility Among Mouse Strains Reverses with Low Concentrations of Carcinogen

Abstract
Ten mouse strains in which aryl hydrocarbon hydroxylase can be induced, or F 1 hybrids of these strains, were ranked according to their sarcoma susceptibility when exposed to a high concentration (5 percent) of the chemical carcinogen 3-methylcholanthrene. This rank order was reversed when the concentration of 3-methylcholanthrene was reduced to 0.05 percent.