Eosinophilic granulocyte deficiency in mice mutant insl andw loci

Abstract
HomozygousSl/Sl andW v/W v mice were found to have approximately 15% of the normal number of circulating eosinophils. Furthermore, these mice exhibited reduced numbers of eosinophilic granulocytes in the bone marrow, spleen and thymus as compared to littermate control normal mice.