Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration
- 4 March 2004
- journal article
- case report
- Published by Wiley in Movement Disorders
- Vol. 19 (7) , 817-821
- https://doi.org/10.1002/mds.20040
Abstract
Positron emission tomography (PET) using [11C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left‐sided symptoms was studied using fluorodeoxyglucose (FDG) and [11C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [11C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD. © 2004 Movement Disorder SocietyKeywords
This publication has 13 references indexed in Scilit:
- In vivo visualization of activated glia by[11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesionBrain, 2001
- In-vivo measurement of activated microglia in dementiaThe Lancet, 2001
- The peripheral benzodiazepine binding site in the brain in multiple sclerosisBrain, 2000
- A Quantitative Study of the Pathological Lesions in the Neocortex and Hippocampus of Twelve Patients with Corticobasal DegenerationExperimental Neurology, 2000
- Fluorodopa uptake and glucose metabolism in early stages of corticobasal degenerationZeitschrift für Neurologie, 1999
- PK (‘peripheral benzodiazepine’) – binding sites in the CNS indicate early and discrete brain lesions: microautoradiographic detection of [3H]PK 11195 binding to activated microgliaJournal of Neurocytology, 1997
- Magnetic Resonance Imaging of Corticobasal DegenerationJournal of Neuroimaging, 1996
- Microglia: a sensor for pathological events in the CNSTrends in Neurosciences, 1996
- CORTICOBASAL DEGENERATIONBrain, 1989
- Corticodentatonigral Degeneration With Neuronal AchromasiaArchives of Neurology, 1968