ONTOGENIC DEVELOPMENT AND TISSUE DISTRIBUTION OF RENAL PROXIMAL TUBULE BRUSH-BORDER MEMBRANE ANTIGENS IN DOG

  • 1 January 1978
    • journal article
    • research article
    • Vol. 32  (3) , 405-410
Abstract
Using an antibody raised against highly purified dog renal proximal tubule brush border membranes, the tissue distribution and ontogenic development of antigens sharing specificity with those in the renal brush border membrane were investigated. The antigens were found in the small intestine, gall bladder, epididymis, pancreas, salivary gland, lacrimal gland, liver and spleen. Examination of embryos at various stages of gestation revealed that the antigens make their appearance early in organogenesis, and are present in the cytoplasm as well as on the membrane during fetal development. Absorption studies showed that at least 2 populations of antigens are present in the kidney. One appears to be kidney-specific and the other is shared by many epithelia. Maltase was identified as 1 of the shared antigens.