Characterization of a mouse interferon gene locus II. Differential expression of α-interferon genes
Open Access
- 1 January 1985
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 13 (3) , 825-839
- https://doi.org/10.1093/nar/13.3.825
Abstract
A cluster of four MuIFN-α genes was recently isolated and characterized (1); one of the genes in this cluster had, in the coding region, an internal deletion of 5 amino acids. Bacterial expression plasmids were constructed to examine the effect of this deletion on the antiviral activity of the MuIFN-α4 peptide and it was found that α4 interferon peptide had a 100-fold lower antiviral activity than full length α-interferon proteins when expressed in E.coli.Keywords
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