The effects of naloxone in chronic schizophrenia
- 1 July 1981
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 138 (7) , 913-918
- https://doi.org/10.1176/ajp.138.7.913
Abstract
In a placebo-controlled, double-blind crossover study of 14 male chronic schizophrenic patients, high doses of the opiate antagonist naloxone were given i.v. Hallucinations measured on a verbal-report scale were significantly decreased after naloxone administration. This apparent action of naloxone is apparently mediated by central opiate receptors and it may result from an interaction between central endorphin systems and central catecholaminergic neurons.This publication has 37 references indexed in Scilit:
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