Macrophage-Enhanced Germination of Bacillus anthracis Endospores Requires gerS
Open Access
- 1 October 2002
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 70 (10) , 5870-5872
- https://doi.org/10.1128/iai.70.10.5870-5872.2002
Abstract
Germination of Bacillus anthracis Sterne and plasmidless Δ-Sterne endospores was dramatically enhanced in RAW264.7 macrophage-like cells, while germination of nonpathogenic Bacillus endospores was not. Elimination of gerS, a germinant receptor locus, caused a complete loss of cell-enhanced germination, implicating gerS in the breaking of endospore dormancy in vivo.Keywords
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