Relation between Total Serum IgE Levels and IgE Antibody Production in Rats

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Abstract
Five different rat strains were immunized with 100 μg ovalbumin and 1 mg Al (OH)3. A good correlation was found between the total serum IgE level of a rat strain before immunization and the IgE antibody production. Good IgE antibody-producing strains had high total serum IgE levels and vice versa. A discordance between the evolution of the total serum IgE level after immunization and the changes in IgE antibody level was found in all strains.