CLINICAL AND LABORATORY STUDIES OF LEVAMISOLE IN PATIENTS WITH RHEUMATOID-ARTHRITIS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 47  (187) , 385-400
Abstract
Two studies with levamisole in rheumatoid arthritis were reported. In the 1st study of 30 patients, levamisole was superior to placebo in terms of pain relief, reduction in articular tenderness, duration of morning stiffness, erythrocyte sedimentation rate (ESR) and radioisotope uptake in knee and wrist joints. There were no consistent differences in lymphocyte function, immunoglobin or complement concentration, or polymorphonuclear granulocytic function. In the 2nd study 40 patients were treated with gold therapy or levamisole. At the end of 1 yr there were significant improvements with both regimens in pain score, joint tenderness and ESR. The patients on levamisole showed significant improvement of duration of morning stiffness, while the patients on gold showed significant improvement of rheumatoid factor titer and left hand grip, but there were no significant differences between the 2 regimens.

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