Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns
- 2 December 2005
- journal article
- clinical trial
- Published by Wolters Kluwer Health in AIDS
- Vol. 19 (18) , 2167-2169
- https://doi.org/10.1097/01.aids.0000194800.43799.94
Abstract
The administration of single-dose nevirapine to women in labor and their infants can prevent HIV-1 mother-to-child transmission. We examined nevirapine resistance in infants who were HIV-1 infected despite single-dose nevirapine prophylaxis, including 18 Ugandan infants (HIVNET 012 trial, nine subtype A and nine subtype D) and 23 Malawian infants (NVAZ trial, all subtype C). Nevirapine resistance was more frequent in infants with subtype C than with subtypes A and D (87 versus 50%, P = 0.016).Keywords
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