Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum
Top Cited Papers
- 16 April 2004
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 304 (5669) , 441-445
- https://doi.org/10.1126/science.1094786
Abstract
The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy humans and animals, and causes an unrelenting infection in immunocompromised individuals such as AIDS patients. We report the complete genome sequence of C. parvum , type II isolate. Genome analysis identifies extremely streamlined metabolic pathways and a reliance on the host for nutrients. In contrast to Plasmodium and Toxoplasma , the parasite lacks an apicoplast and its genome, and possesses a degenerate mitochondrion that has lost its genome. Several novel classes of cell-surface and secreted proteins with a potential role in host interactions and pathogenesis were also detected. Elucidation of the core metabolism, including enzymes with high similarities to bacterial and plant counterparts, opens new avenues for drug development.Keywords
This publication has 27 references indexed in Scilit:
- The Cryptosporidium Oocyst Wall Protein Is a Member of a Multigene Family and Has a Homolog in ToxoplasmaInfection and Immunity, 2004
- Integrated Mapping, Chromosomal Sequencing and Sequence Analysis ofCryptosporidium parvumGenome Research, 2003
- Dissecting Apicoplast Targeting in the Malaria Parasite Plasmodium falciparumScience, 2003
- Genome sequence of the human malaria parasite Plasmodium falciparumNature, 2002
- The genome sequence of Schizosaccharomyces pombeNature, 2002
- Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculiNature, 2001
- A Re‐annotation of the Saccharomyces cerevisiae GenomeComparative and Functional Genomics, 2001
- Mediation ofCryptosporidium parvumInfection In Vitro by Mucin-Like Glycoproteins Defined by a Neutralizing Monoclonal AntibodyInfection and Immunity, 2000
- A novel multi-domain mucin-like glycoprotein of Cryptosporidium parvum mediates invasion,Molecular and Biochemical Parasitology, 1998
- An Eimeria tenella gene encoding a protein with homology to the nucleotide transhydrogenases of Escherichia coli and bovine mitochondriaMolecular and Biochemical Parasitology, 1993