Antihypertensive Activity of a New Agent, Indapamide: A Double-Blind Study

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Abstract
SummaryIn a double-blind trial in 22 patients with mild to moderate essential hypertension, indapamide was compared with chlorothiazide and placebo. Dosage levels were set at 5 mg. indapamide and 500 mg. chlorothiazide daily, for 5 days out of 7, and patients were treated alternately, in random sequence, with each drug for a month over a 3-month period. Blood pressure readings and blood chemistry investigations were carried out before and after each treatment period and a careful history was kept of subjective symptoms and patients' tolerance of therapy.The results show that both active treatments produced drops in systolic and diastolic pressures, but were only statistically significant and different from placebo in the case of indapamide. Indapamide also produced much greater subjective improvement (74 %) inpatients with functional symptoms compared with chlorothiazide (15 %).In an overall assessment, indapamide produced an excellent to good response to treatment in 57% of patients. Comparable responses...

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