Dose-Response Curve for Chromosome Translocations Measured in Human Lymphocytes Exposed to 60Co Gamma Rays

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Abstract
Chromosome painting was employed to measure frequencies of reciprocal translocations in human lymphocytes induced b by 60Co gamma rays, with emphasis on low doses. Translocations and dicentrics were distinguished by use of a pan-centromeric probe. A total of 41,151 metaphases were analyzed at doses below 0.2 Gy. The linear “take-off” slope of the linear-quadratic dose response curve for translocations, i.e., the alpha coefficient, was measured to be 0.023 +/− 0.005 translocations per cell per Gy. This alpha coefficient is more precise than previously measured. Because the alpha coefficient is the dominant contributor to the translocation frequency induced by low-level exposures, the results presented here will substantially reduce uncertainties in biodosimetry estimates obtained for stable translocations.

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