Changes in Renin Content in Kidneys of Renal Hypertensive Rats

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Abstract
Summary The renin content of fresh kidney tissue was assayed indirectly by a modification of Schaffenburg's method(3) in rats with experimental renal hypertension, under a variety of conditions. Clamping one renal artery caused an increased concentration of renin in the clamped kidney, and a fall in the contralateral kidney. Clamping both renal arteries also caused an increase in renin content of the more efficiently clamped kidney and a decrease in the contralateral kidney. Renin content in the one remaining kidney was not influenced by unilateral nephrectomy in normal rats. Clamping the one remaining renal artery in unilaterally nephrectomized rats induced hypertension, but did not result in an increase in renin content of the kidney. Similarly, removal of the undamped kidney in rats with hypertension due to a unilateral renal artery clip resulted in a slow decrease of renin content in the clamped kidney to normal values. Removal of the clamped kidney in such animals caused a rapid fall of blood pressure and a subsequent slow increase of renin content in the remaining undamped kidney. A unifying hypothesis to explain these changes is presented, involving a concept of renin inhibition or inactivation.

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