An Experimental Study on the Endurance of Immunologic Memory of Intradermal Micro-Injection with Rabies Vaccine and Boosting Immune Effect
Open Access
- 1 January 1999
- journal article
- clinical trial
- Published by Japan Epidemiological Association in Journal of Epidemiology
- Vol. 9 (4) , 209-215
- https://doi.org/10.2188/jea.9.209
Abstract
The purpose of the experimental study is to observe the effect of the immune recall responses induced by intramuscular (IM) injection with concentrated Primary Hamster Kidney Cell Vaccine(PHKCV) on days 180, 365, 545 and 730 after 0.1 mL nonconcentrated PHKCV was inoculated intradermally (ID), so as to determine the duration of the immunologic memory induced by ID 0.1 mL nonconcentrated PHKCV and chieve the goal of protecting the rabies patients with a short incubation . The results indicated that there were four intervals of 180, 365, 545 and 730 days between ID and IM PHKCV, the seroconversion rates being respectively 96.55%, 100%, 100%(180 day); 76.67%, 100%, 100%(365 day); 75.86%, 100%, 100%(545 day) and 75.00%, 100%, 100%(730 day) on days 7, 14 and 30 after the first dose IM, the seroconversion rates of four experimental groups were all markedly higher than that of five routine doses (40.74%) (PJ Epidemiol, 1999 ; 9 : 209-215.Keywords
This publication has 0 references indexed in Scilit: