PROLONGED RENAL-FAILURE AFTER RIFAMPIN

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Abstract
A 45 yr old man treated for pulmonary tuberculosis with daily drug therapy, including rifampin developed acute renal failure manifested by eosinophilia, skin rash and increased serum blood urea N and creatine. Renal failure was marked by a prolonged course and incomplete recovery. Renal biopsy showed tubulointerstitial nephritis with nonspecific glomerular mesangial proliferation. Fluorescence staining showed Ig[immunoglobulin]G, IgA, IgM and C3 [3rd complement component] deposits in glomeruli and IgE deposits along tubules. This report describes a new hazard of rifampin therapy that may have developed, in part, due to coexisting hepatic dysfunction.