The Erythropoietic Effect of Hematocrit Variations in Normovolemic Rabbits
Open Access
- 1 May 1966
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 27 (5) , 629-636
- https://doi.org/10.1182/blood.v27.5.629.629
Abstract
Measurements of erythropoietin titer and serum iron turnover were carried out in rabbits 48 hours after the induction of normovolemic anemias and polycythemias. Although viscosity studies of blood at various hematocrits indicate that the oxygen flow to the tissues is impaired both in anemia and polycythemia, only anemias were found to be associated with production of erythropoietin and with accelerated serum iron turnover. It was concluded that if polycythemia with its associated high viscosity leads to tissue hypoxia, this tissue hypoxia will not cause production of erythropoietin.This publication has 1 reference indexed in Scilit:
- Hemodynamic effects of normovolemic polycythemia in dogs at rest and during exerciseAmerican Journal of Physiology-Legacy Content, 1964