Transfer and Decline of Maternal Infectious Canine Hepatitis Antibody in Puppies

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Abstract
Maternal serum antibody titers were correlated with puppy serum antibody titers when the full complement of maternal antibody, principally in the form of colostrum, was acquired. Maximal titers were estimated to occur at or before 72 hours, but not 8 to 12 hours after birth. The relationship between puppy antibody titers and the maternal antibody titer could be expressed as: log10 puppy titer = -.16 + .92 log10 mother titer. The rate of maternal antibody decline in puppies was regular, and the half-life of infectious canine hepatitis virus neutralizing antibody was calculated to be 8.6 days. A relationship also was established between the puppy titer as a proportion of the log10 maternal titer, and rate of antibody decay. This could be expressed as: Puppy titer = Mother titer -.25T (age in weeks).

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