DETECTION OF RETROVIRUS PARTICLES AND REVERSE-TRANSCRIPTASE ACTIVITY IN MIDTERM CULTURED PERIPHERAL-BLOOD AND LYMPH-NODE CELLS FROM A FRENCH WOMAN WITH SEZARY-SYNDROME
- 1 January 1989
- journal article
- research article
- Vol. 31 (5) , 333-337
Abstract
Retrovirus particles, with an ultrastructure of type C-virus similar to HTLV-1 were observed in several mid-term cultures of leukemic cells derived from a woman with a well characterised Sezary syndrome who had always resided in France. Reverse transcriptase activity was detected in supernatant fluids from day 6 to day 40 of culture. However, negative anti HTLV-1 serology and the absence of specific molecular hybridization between leukemic cell DNA and two HTLV-1 derived probes, argue against a HTLV-1 virus.This publication has 5 references indexed in Scilit:
- Characterization of htlv‐i isolates and t lymphoid cell lines derived from french west indian patients with tropical spastic paraparesisInternational Journal of Cancer, 1989
- C-type particles are inducible in Se-Ax, a continuous T-cell line from a patient with Sézary's syndromeArchives of Dermatological Research, 1988
- HTLV-V: a New Human Retrovirus Isolated in a Tac-Negative T Cell Lymphoma/LeukemiaScience, 1987
- Human T cell gamma genes are frequently rearranged in B-lineage acute lymphoblastic leukemias but not in chronic B cell proliferations.The Journal of Experimental Medicine, 1987
- Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaProceedings of the National Academy of Sciences, 1980