METABOLISM OF DOGS DURING INTOXICATION FROM AGENIZED WHITE WHEAT FLOUR

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Abstract
The metabolism of 6 dogs was studied intensively to determine what, if any, changes occur in conjunction with intoxication from the ingestion of agenized white wheat flour. There was a large increase in serum acetylcholine and a striking decrease in serum cholinesterase activity during intoxication. These changes were progressive, being greatest toward the end of the period of intoxication. No impairment of kidney or liver function could be detected at any time, as judged by widely used clinical and laboratory criteria. No consistent or biologically significant changes during the course of intoxication were detected in erythrocyte count, leukocyte count, blood Hb, hematocrit, blood glucose, serum N.P.N., serum total protein, serum albumin, serum globulin, serum A/G ratio, serum urea N, serum inorganic P, serum Ca, urinary total N, urinary urea N, urinary creatinine, urinary Ca or urinary P.