Increased basal gluconeogenesis in the aged rat
- 3 March 1986
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 197 (1-2) , 159-163
- https://doi.org/10.1016/0014-5793(86)80318-0
Abstract
Post‐absorptive gluconeogenesis from lactate measured in vivo increases 3‐fold in 24‐month‐old rats compared to 3‐month‐old animals. Fractional lactate turnover rates showed no significant differences between the two groups of animals. Lower plasma glucose concentrations and insulin‐glucagon ratios may explain the increase in gluconeogenesis observed in aged rats.Keywords
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