Possible association of schizophrenia with a disturbance in prostaglandin metabolism: a physiological hypothesis
- 1 August 1976
- journal article
- research article
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 6 (3) , 359-369
- https://doi.org/10.1017/s0033291700015798
Abstract
Schizophrenia may be associated with increased prostaglandin synthesis in certain parts of the brain. This hypothesis is based on the following findings: (1) Catalepsy, which is the nearest equivalent in animals to human catatonia, develops in cats when prostaglandin E1 is injected into the cerebral ventricles and when during endotoxin or lipid A fever the prostaglandin E2 level in cisternal c.s.f. rises to high levels; however, when fever and prostaglandin level are brought down by non-steroid anti-pyretics which inhibit prostaglandin synthesis, catalepsy disappears as well. (2) Febrile episodes are a genuine syndrome of schizophrenia.Keywords
This publication has 34 references indexed in Scilit:
- A dissociation between fever and prostaglandin concentration in cerebrospinal fluid.The Journal of Physiology, 1975
- Lipid A fever in cats.The Journal of Physiology, 1975
- Inhibition of prostaglandin synthetase by psychotropic drugsCellular and Molecular Life Sciences, 1975
- Further studies on the role of prostaglandin in feverThe Journal of Physiology, 1974
- Phenothiazine Deaths: A Critical ReviewAmerican Journal of Psychiatry, 1973
- Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbitsThe Journal of Physiology, 1971
- Prostaglandins and AspirinNature, 1971
- ACTIONS OF PROSTAGLANDINS E1, E2 AND E3 ON THE CENTRAL NERVOUS SYSTEMBritish Journal of Pharmacology and Chemotherapy, 1964
- Hauttemperaturmessungen bei zentralen FieberstörungenZeitschrift für Neurologie, 1935
- HEAT PRODUCTION AND HEAT CONTROL IN THE SCHIZOPHRENIC REACTIONArchives of Neurology & Psychiatry, 1934