MORPHOGENESIS OF VESICULATION IN FOOT-AND-MOUTH-DISEASE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 41  (9) , 1537-1542
Abstract
The morphogenesis of vesiculation in cattle inoculated (aerosol exposure) with foot-and-mouth disease virus was investigated by examining alternate, frozen sections of selected tissues stained by fluorescent antibody technique and with hematoxylin and eosin. Viremia preceded the development of lesions and virus appeared to be transported to the epithelium via papillae. Lesions were initiated usually by the infection of single cells in the stratum spinosum adjacent to the papillae. Three types of lesions were observed. A vesicle developed mainly from the lysis of swollen, spherical cells and the release of intracellular fluid. The 2nd type of lesion was formed mainly by the accumulation of intercellular edema. The 3rd type was characterized by the absence of a vesicle due to seepage and loss of edema fluid and desiccation of the lesion.

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