MyD88 as a Bottle Neck in Toll/IL-1 Signaling
- 1 January 2002
- book chapter
- Published by Springer Nature
- Vol. 270, 155-164
- https://doi.org/10.1007/978-3-642-59430-4_10
Abstract
Myeloid differentiation factor 88 (MyD88) is an adaptor molecule composed of an N-terminal death domain and a C-terminal Toll/interleukin (IL)-1R homology domain. Ligand binding to Toll-like receptor (TLR)/IL-1R family members results in the association of MyD88 to the cytoplasmic tail of receptors; this then initiates the signaling cascade that leads to the activation of nuclear factor-кB and mitogen-activated protein kinases. Analysis of MyD88-deficient mice revealed its essential role in TLR/IL-1R signaling as well as in both the innate and the adaptive immune response.Keywords
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