THE EXPERIMENTAL PRODUCTION OF HERPETIC LESIONS

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Abstract
The etiology of herpetic eruptions in man is by no means completely solved, and more precise knowledge of the subject is comparatively recent in origin. It was not until 1900 that Head and Campbell definitely established the morphologic pathology of herpes zoster by the demonstration that the herpetic eruption is associated with acute interstitial inflammation of the dorsal root ganglions, or of their homologues on the cranial sensory nerves. The presumable involvement of some infective agent in the pathogenesis of herpes of this type has long been suspected. The important observation of the production of an experimental disease in animals with a virus from herpes febrilis or simplex, which is clinically and pathologically analogous to the human disease herpes zoster, was announced not long ago by Teague and Goodpasture.1Further details have now been published.2In order to render the skin of experimental animals more susceptible to the

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