Hemoglobin Carbamylation in Uremia

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Abstract
CHROMATOGRAPHY of hemolysates of red cells resolves four minor hemoglobin components from the main hemoglobin A (HbA) fraction. These minor components — HbA1a1, HbA1a2, HbAlb, and HbA1c — collectively referred to as the HbA1 fraction, make up approximately 7 per cent of total hemoglobin in normal subjects and result mainly from the post-translational, nonenzymatic glycosylation of HbA.1 In HbAlc, the most abundant of the glycosylated hemoglobins, glucose is attached to the N-terminal amino group of the β chains by a stable ketoamine linkage; HbA1c is present in increased amounts . . .