A Partial Sequence of Nuclear Events in Regenerating Rat Liver
- 1 January 1972
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (1) , 7-10
- https://doi.org/10.1073/pnas.69.1.7
Abstract
When two lobes of the liver of the adult rat are removed, the cells of the remaining lobe are aroused to renewed cell division. We have studied the early events in such regeneration. The first observable response to such partial hepatectomy is the production in the liver nuclei of rapidly-labeled high-molecular-weight RNA of sequences not produced by normal liver. This is followed, with a lag of about 1 hr, by the appearance of increased (above normal) amounts of chromosomal RNA, again of sequences not produced by normal liver. With a lag of another hour, the template activity in support of RNA synthesis of the liver chromatin increases substantially. These events occur before initiation of DNA synthesis in the cells of the regenerating liver.Keywords
This publication has 16 references indexed in Scilit:
- Tissue Differences in Rat Chromosomal RNAProceedings of the National Academy of Sciences, 1971
- Association of Chromosomal RNA with Repetitive DNAProceedings of the National Academy of Sciences, 1971
- Gene Regulation for Higher Cells: A TheoryScience, 1969
- Chromosomal ribonucleic acid of rat ascites cellsBiochemistry, 1969
- Sequence-specific interaction of DNA and chromosomal proteinJournal of Molecular Biology, 1969
- The Biology of Isolated ChromatinScience, 1968
- The introduction of radioisotopes into RNA by methylation in vitroBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1967
- Ribonucleic acid synthesis in regenerating and embryonic liverJournal of Molecular Biology, 1967
- Histone-bound RNA, a component of native nucleohistone.Proceedings of the National Academy of Sciences, 1965
- DEOXYRIBONUCLEIC ACID-DIRECTED SYNTHESIS OF RIBONUCLEIC ACID BY AN ENZYME FROM ESCHERICHIA COLIProceedings of the National Academy of Sciences, 1962