High-Dose Intravenous Immunoglobulin for Post-Transfusion Purpura

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Abstract
Successful treatment of a case of post-transfusion purpura with high-dose i.v. human Ig is reported. A 62-yr-old multiparous woman developed severe thrombocytopenia in the wake of transfusions given during and after vascular surgery. A platelet alloantibody with anti-Zwa-specificity was demonstrable by an indirect immunofluorescence technique. A single infusion of Sandoglobulin 1 g/kg body wt caused an immediate platelet response with cessation of hemorrhagic manifestations within 12 h, and the platelet count became normal within 3 d. Thrombocytopenia recurred 8 d after the infusion, but 1 further dose of Sandoglobulin 0.5 g/kg body weight caused definitive reversal of the thrombocytopenia.