EFFECT OF LARGE DOSES OF ESTROGENS ON THE BLOOD PICTURE OF DOGS

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Abstract
Aplastic anemia developed after a latent period of 1-3 wks. in normal dogs of both sexes and in castrated $ dogs after treatment with large doses of estrone, estradiol benzoate or diethylstilbestrol. The most striking effect was a fall in the number of leucocytes after an initial leukocytosis. When daily injs. of 5 mg. in 1 cc. of olive oil were given until the onset of severe symptoms, the fatal total dose of estradiol benzoate lay between 8 and 16 mg. per kg. of body wt. The total quantity of estrogen tolerated depended upon the daily dose. A dose of 5 mg. given daily for 16 to 40 days was fatal for a dog of 10 kg., while a dose of 1 mg. daily for as long as 9 mos. was harmless. Testosterone did not produce anemia even when given daily for several mos. Androgens injected simultaneously with estrogens did not prevent the toxic effect of the latter. The anemia was not prevented by the simultaneous inj. of liver extracts.