Challenges in the development of mGluR5 positive allosteric modulators: The discovery of CPPHA

This publication has 12 references indexed in Scilit:

• The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices
  European Journal of Pharmacology, 2006
• Allosteric Potentiators of Metabotropic Glutamate Receptor Subtype 5 Have Differential Effects on Different Signaling Pathways in Cortical Astrocytes
  The Journal of Pharmacology and Experimental Therapeutics, 2005
• Discovery of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 (mGluR5)
  Current Topics in Medicinal Chemistry, 2005
• A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models
  The Journal of Pharmacology and Experimental Therapeutics, 2005
• Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors
  Bioorganic & Medicinal Chemistry Letters, 2005
• Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series of N-(1,3-Diphenyl-1H- pyrazol-5-yl)benzamides That Potentiate Receptor Function in Vivo
  Journal of Medicinal Chemistry, 2004
• A Novel Selective Allosteric Modulator Potentiates the Activity of Native Metabotropic Glutamate Receptor Subtype 5 in Rat Forebrain
  The Journal of Pharmacology and Experimental Therapeutics, 2004
• A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5
  Molecular Pharmacology, 2003
• Development of a Custom High-Throughput Preparative Liquid Chromatography/Mass Spectrometer Platform for the Preparative Purification and Analytical Analysis of Compound Libraries
  Journal of Combinatorial Chemistry, 2003
• Polymer-Supported Quenching Reagents for Parallel Purification
  Journal of the American Chemical Society, 1997