Angiotensin-(1–7) Attenuates Neointimal Formation After Stent Implantation in the Rat

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Abstract
Angiotensin-(1–7) is an endogenous, biologically active peptide of the renin-angiotensin system with vasodilatory, antithrombotic, and antiproliferative properties. This study examined the effects of angiotensin-(1–7) infusion on neointimal formation after stent placement in the rat. Male Wistar rats underwent stent implantation in the abdominal aorta or sham surgery. Subsequently, an osmotic minipump was placed for angiotensin-(1–7) (24 μg/kg per hour) or saline administration. After 4 weeks, histomorphometric and histological analyses were performed, and the endothelial function was measured in isolated thoracic aortic rings. Stent implantation resulted in equal mean injury scores within the groups. The angiotensin-(1–7)–treated group displayed a significant reduction in neointimal thickness (112±8 versus 141±11 μm; P 2 ; P P P <0.001). In conclusion, angiotensin-(1–7) treatment attenuates neointimal formation after stent implantation in the rat, combined with an improvement of endothelial function.