Spectral Characteristics of Human Atrial Fibrillation Waves of the Right Atrial Free Wall With Respect to the Duration of Atrial Fibrillation and Effect of Class I Antiarrhythmic Drugs.

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Abstract
The aim of this study was to use fast Fourier transform analysis to clarify the characteristics of human atrial fibrillation (AF) waves with respect to the duration of AF and the effect of class I antiarrhythmic drugs. Twenty-two patients (10 paroxysmal AF, 12 persistent AF) without organic heart disease were studied by conventional electrophysiological methods. Electrograms were recorded from the right atrial free wall during AF and spectral analysis was performed for 35 s (16 consecutive 4096-ms epochs with 50% overlap) and the fibrillation cycle length (FCL) was calculated from the peak frequency. Mean FCL and SD were determined from 16-epoch data, and the temporal variability of FCL was defined as the SD of FCL. Paroxysmal AF had a longer mean FCL than persistent AF (178 ±26 ms vs 139±16 ms, pJpn Circ J 2001; 65: 1047 - 1051)