Changes in plasma noradrenaline concentration following sympathetic stimulation by gradual tilting

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Abstract
Plasma noradrenaline concentration was determined by a radioenzymatic method in 10 normal individuals who were subjected to a stepwise tilt through 45°. A gradual increase in noradrenaline was observed with maximal values occurring in most subjects following the full 45° of tilt. Maximal levels were sustained for up to 30 min. In two subjects who fainted, the syncopal episode followed an initial sympathetic postural response as shown by a rise in plasma noradrenaline. For the remaining subjects a significant correlation was found between changes in plasma noradrenaline and mean arterial pressure.

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