Measles immunization. Successes and failures

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Abstract
As a result of a large community outbreak of measles, measles hemagglutination inhibition (HI) titers were measured in 465 immunized children. Titers of < 1:4 were found in 14.6% of children immunized at 12 mo. old as compared to 5.2% of those immunized at .gtoreq. 13 mo. old. Measles antibody titers were higher in the mothers of seronegative children who were immunized at 11 or 12 mo. old than in the mothers of seropositive children. Measles HI titers of .gtoreq. 1:4 were present in 94% of children immunized at .gtoreq. 13 mo. old from 1962-1964. Vaccine failure, and not waning antibody, apparently accounts for the majority of titers of < 1:4 in immunized children. Reimmunization programs should be considered for those who were immunized before 13 mo. old.

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