PLASMA LEVELS OF PROGESTERONE DURING THE LUTEAL PHASE IN NORMAL WOMEN TREATED WITH SYNTHETIC OESTROGENS (RS 2874, F 6103 AND ETHINYLOESTRADIOL)

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Abstract
Three synthetic oestrogens (RS 2874, F 6103 and ethinyloestradiol)1) were given orally during the luteal phase to healthy young women. The compounds were administered for various periods of time starting on the third day following ovulation. The changes of the daily plasma levels of progesterone and the length of the luteal phase were studied. The highest dose of RS 2874 was 60 mg daily for 8 days, that for F 6103, 300 mg daily for 6 days and that for ethinyloestradiol, 200 μg daily for 8 days. The doses were selected to give approximately the same oestrogenic effects in women, using the proliferative activity of the endometrium as an end point. In the cycles treated with RS 2874 and ethinyloestradiol the length of the luteal phase was shortened by one to two days and the sum of the daily plasma levels of progesterone was decreased accordingly. No differences were seen between the control cycles and the cycles treated with F 6103. The doses of the three compounds used did not seem to delay the onset of menstrual bleeding. The lack of antifertility effect of F 6103 and of ethinyloestradiol when given after ovulation as reported by other investigators, agree well with the minor changes in the corpus luteum function found in this study.

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