Acetate Metabolism in Experimental Virus-Induced Disease

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Abstract
The influence of experimental poliomyelitis on the oxidative metabolism of acetate by mice was studied employing an apparatus designed to measure respiratory radioactivity excretion. The mice were given sodium acetate-2-C14 and the excretion of breath C14O2 measured over a 7-hour period. Animals infected with poliomyelitis virus oxidized acetate at a one-third lower peak rate initially following administration of substrate. After 7 hours, about 5% more total C14O2 was excreted by mice manifesting paralytic symptoms of central nervous system involvement than by normal mice. This lack of any large effect is of particular interest considering the changes in physiological conditions associated with paralytic poliomyelitis.

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