6-Aminopyrazolo[4,3-c]pyridin-4(5H)-one, a novel analog of guanine
- 1 February 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (2) , 317-318
- https://doi.org/10.1021/jm00212a030
Abstract
Treatment of dimethyl .alpha.-ethoxymethylidineacetonedicarboxylate with hydrazine gave methyl 3-(methoxycarbonylmethyl)pyrazole-4-carboxylate which, upon ammonolysis and dehydration, afforded methyl 3-(cyanomethyl)pyrazole-4-carboxylate. This compound, when heated with liquid ammonia, gave 6-aminopyrazolo[4,3-c]pyridin-4(5H)-one, a new guanine analogue, which did not possess any of the potent antiviral activity shown by 6-aminoimidazo[4,5-c]pyridin-4(5H)-one (3-deazaguanine).This publication has 0 references indexed in Scilit: